H. Kawashima et al., DEVELOPMENT OF STEP-SPECIFIC PET TRACERS FOR STUDYING FATTY-ACID BETA-OXIDATION - BIODISTRIBUTION OF [1-C-11] OCTANOATE ANALOGS IN RATS ANDA CAT, Nuclear medicine and biology, 25(6), 1998, pp. 543-548
To evaluate the potential of [1-C-11]-3-(R,S)-methyloctanoate (BMOA),
[1-C-11]-2-octynoate, and [1-C-11]-2-decynoate as PET tracers for stud
ying particular steps in fatty acid beta-oxidation, we examined the ph
armacokinetics of these compounds in rats and a cat. In rats given the
se compounds, high levels of radioactivity accumulated in the heart, l
iver, and kidneys, suggesting their potential as tracers for studying
beta-oxidation in these tissues. These organs were clearly visible wit
h PET in a cat given BMOA, indicating the utility of BMOA for imaging
these organs. NUCL MED BIOL 25;6:543-548, 1998. (C) 1998 Elsevier Scie
nce Inc.