NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF AZATRIPEPTIDE ANALOGS

Authors
LIU SF XU JC
Citation
Sf. Liu et Jc. Xu, NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF AZATRIPEPTIDE ANALOGS, Huaxue xuebao, 56(7), 1998, pp. 707-713
Citations number
1
Categorie Soggetti
Chemistry
Journal title
Huaxue xuebao → ACNP
ISSN journal
05677351
Volume
56
Issue
7
Year of publication
1998
Pages
707 - 713
Database
ISI
SICI code
0567-7351(1998)56:7<707:NAE-SA>2.0.ZU;2-H
Abstract
A series of azatripeptide analogs were designed and synthesized. The i n vitro inhibitory activities of these compound's toward angiotensin c onverting enzyme (ACE) were evaluated. Furthermore,the structure-activ ity relationship of these compound was discussed. The results showed t hat azaalanine was a good isosterer of alanine in angiotensin converti ng enzyme inhibitors.