The aim of this study was to contrast the prevalence of allergic sympt
oms in children living in urban and rural areas of Saudi Arabia and to
investigate factors associated with any differences found, A cross-se
ctional questionnaire survey was conducted of a social class-stratifie
d sample of 1,020 urban and 424 rural 12 yr old children, recording sy
mptoms of current and past allergic disease and doctors' diagnoses, to
gether with nationality and the fathers' educational level and occupat
ions, A significantly greater prevalence of allergic symptoms was foun
d in urban than in rural children and in Saudi than in non-Saudi Arab
children. Males were more likely to have some respiratory symptoms and
Females had more eye and skin symptoms. Educational level and occupat
ion of the father did not influence the likelihood of having symptoms,
Logistic regression analyses showed that urban residence and Saudi na
tionality were the two main risk factors associated with asthmatic sym
ptoms. There is likely to have been a recent increase in the prevalenc
e of allergic disease in Saudi children associated with increased affl
uence, which has not affected non-Saudi migrants moving into the same
environment to the same extent. This is consistent with the hypothesis
that the environment, possibly through changes in lifestyle and patte
rns of infection, influences the expression of allergic disease.