Citation
Pv. Pogrebnoy et al., A PROTEIN-KINASE INHIBITOR FROM A431 SUBLINE OVEREXPRESSING TGF-ALPHAPOSSESSES ANTIMICROBIAL ACTIVITY, The New microbiologica, 21(3), 1998, pp. 269-273
Citations number
12
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138
→ ACNP
Volume
21
Issue
3
Year of publication
1998
Pages
269 - 273
Database
ISI
SICI code
1121-7138(1998)21:3<269:APIFAS>2.0.ZU;2-8
Abstract
During the last decade the key role of antimicrobial peptides in innat
e immunity has been argued. They were found in plants and in different
phylogenic groups of animals (insects, amphibia, and even in mammals)
. We report the production of a human peptide antibiotic that was prev
iously characterized as an EGF re; ceptor tyrosine kinase inhibitor in
epidermoid carcinoma A431/1522 cell subline overexpressing TGF alpha.
It is a 3 kDa hydrophobic cationic peptide cytotoxic for different sp
ecies of Gr+ and Gr- bacteria in micromolar concentration range, and d
emonstrating slight fungicidal.activity.