ANTIBIOTICS AT SUB-INHIBITORY CONCENTRATIONS AND VIRULENCE FACTORS OFPSEUDOMONAS-AERUGINOSA

The difficulty of istituting an efficacious therapy against Pseudomona s aeruginosa infections is principally due to the microorganism's anti biotic resistance. The aim of our study was to evaluate the activity o f four antibacterial drugs, two penems and two quinolones, on the prod uction of virulence factors. Our results demonstrated that the antibio tics tested have a different behaviour depending on the P. aeruginosa phenotype. Therefore it would be advisable to choose the drug on the b asis of the isolated strain phenotype.