Gene therapy for breast cancer is still in the very early stages of de
velopment. Many of the molecular strategics that have been proposed ar
e also being developed for other cancers. Their application to breast
cancer, however, needs to address several issues specific to this dise
ase such as the widespread nature of metastases the indolent growth of
the tumor cells, and the production by the tumor of immunosuppressive
agents. Nonetheless, these approaches appear promising, particularly
those that employ a combination of strategies. Gene therapies that aff
ect the biology of breast cancer cells or regulate host immun mechanis
ms have bren most successful and may be paired with existing therapies
for breast cancer.