A CONVENIENT METHOD FOR THE PREPARATION OF ACYLSULFONAMIDE LIBRARIES

Authors
STURINO CF LABELLE M
Citation
Cf. Sturino et M. Labelle, A CONVENIENT METHOD FOR THE PREPARATION OF ACYLSULFONAMIDE LIBRARIES, Tetrahedron letters, 39(33), 1998, pp. 5891-5894
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
33
Year of publication
1998
Pages
5891 - 5894
Database
ISI
SICI code
0040-4039(1998)39:33<5891:ACMFTP>2.0.ZU;2-3
Abstract
The preparation of an acylsulfonamide library is described using resin bound EDC (1-(3 dimethylaminopropyl)-3-ethylcarbodiimide). A polymer supported sulfonic acid (A-15) is used as a scavenger to remove dimeth ylaminopyridine and purification only involves filtration of the react ion mixture. This method provides the acylsulfonamides products in goo d yields and purity. (C) 1998 Elsevier Science Ltd. All rights reserve d.