LEVELS OF INHIBITORS OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA IN URINE AND SERA OF PATIENTS WITH UROSEPSIS

The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor rec eptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1r a), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in se ra and urine of 30 patients with culture-proven urinary tract infectio ns before and 4, 24, 48, and 72 h after initiation of antibiotic thera py and in 20 healthy individuals, In serum, the levels of sTNFR types I and II, IL-1ra, and IL-10 were higher in patients than in controls. In urine, only sTNFR type I and II levels were elevated in patients. T he ratios of concentrations of both types of sTNFR in urine to concent rations in serum were higher in patients than in controls. These findi ngs indicate that during urosepsis, the antiinflammatory cytokine resp onse is generated predominantly at the systemic level.