FAB-INDEPENDENT ANTIADHESION EFFECTS OF SECRETORY IMMUNOGLOBULIN-A ONS-FIMBRIATED ESCHERICHIA-COLI ARE MEDIATED BY SIALYLOLIGOSACCHARIDES

Authors
SCHROTEN H STAPPER C PLOGMANN R KOHLER H HACKER J HANISCH FG
Citation
H. Schroten et al., FAB-INDEPENDENT ANTIADHESION EFFECTS OF SECRETORY IMMUNOGLOBULIN-A ONS-FIMBRIATED ESCHERICHIA-COLI ARE MEDIATED BY SIALYLOLIGOSACCHARIDES, Infection and immunity, 66(8), 1998, pp. 3971-3973
Citations number
18
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
8
Year of publication
1998
Pages
3971 - 3973
Database
ISI
SICI code
0019-9567(1998)66:8<3971:FAEOSI>2.0.ZU;2-M
Abstract
S-fimbriated Escherichia coli strains cause sepsis and meningitis in n ewborns and are known to recognize the carbohydrate sequence sialyl-(a lpha 2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sial yloligosaccharides on secretory immunoglobulin A (s-IgA), This indicat es an anti-infective function of s-IgA (Fc), particularly in early hum an milk.