BINDING OF THE HELICOBACTER-PYLORI VACUOLATING CYTOTOXIN TO TARGET-CELLS

Authors
MASSARI P MANETTI R BURRONI D NUTI S NORAIS N RAPPUOLI R TELFORD JL
Citation
P. Massari et al., BINDING OF THE HELICOBACTER-PYLORI VACUOLATING CYTOTOXIN TO TARGET-CELLS, Infection and immunity, 66(8), 1998, pp. 3981-3984
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
8
Year of publication
1998
Pages
3981 - 3984
Database
ISI
SICI code
0019-9567(1998)66:8<3981:BOTHVC>2.0.ZU;2-2
Abstract
The vacuolating cytotoxin of Helicobacter pylori, VacA, enters the cyt oplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis, By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA binds to specific high-affinity cell surface receptors and that this interaction is nece ssary for cell intoxication.