SIMPLE, RAPID AND SIMULTANEOUS MEASUREMENT OF 8 DIFFERENT TYPES OF CARBAMATE PESTICIDES IN SERUM USING LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY

We have developed a method for simultaneous analysis of methylcarbamat e pesticides in serum with an acute pesticide intoxication. This is pe rformed by liquid chromatography-atmospheric pressure chemical ionizat ion mass spectrometry. Rapid detection of eight types of methylcarbama te pesticide can be achieved with this method, it only requires an ext remely simple pre-treatment of the sample. The specificity of this met hod is equal to that of gas chromatography-mass spectrometry, and it s atisfies the clinical requirements for detection sensitivity and speci ficity. Although some problems with this analytical method remain to b e solved, we consider it to be superior to any other analytical method previously reported.