MOTILIN INCREASES FOOD-INTAKE IN MICE

Authors
ASAKAWA A INUI A MOMOSE K UENO N FUJINO MA KASUGA M
Citation
A. Asakawa et al., MOTILIN INCREASES FOOD-INTAKE IN MICE, Peptides (New York, N.Y. 1980), 19(6), 1998, pp. 987-990
Citations number
30
Categorie Soggetti
Biology
Journal title
Peptides (New York, N.Y. 1980) → ACNP
ISSN journal
01969781
Volume
19
Issue
6
Year of publication
1998
Pages
987 - 990
Database
ISI
SICI code
0196-9781(1998)19:6<987:MIFIM>2.0.ZU;2-V
Abstract
The effect of motilin on food intake was investigated in nonfood-depri ved mice. A significant increase in food intake was observed 1 h after ICV administration of motilin (3 nmol/mouse) and continued for 2 h. T his effect was attenuated markedly by the motilin receptor antagonist GM-109 (0.3-3 nmol/mouse) in a dose-related manner. GM-109 alone had n o effect on food intake. These results indicate that motilin receptors are present in the brain and may have a role in the regulation of foo d intake. (C) 1998 Elsevier Science Inc.