ATTENUATION OF INTESTINAL AND CARDIOVASCULAR ANAPHYLAXIS BY THE SALIVARY-GLAND TRIPEPTIDE FEG AND ITS D-ISOMERIC ANALOG FEG

The effects of the submandibular gland peptide-T (SGP-T; Thr-Asp-Ile-P he-Gly-Gly; TDIFEGG), its carboxy-terminal fragment (the tripeptide FE G; Phe-Glu-Gly), and the D-isomeric analog (feG) on intestinal and car diovascular anaphylactic reactions were studied. The tripeptides, FEG and feG, when administered intravenously or orally to egg albumin-sens itized Hooded Lister or Sprague-Dawley rats 30 min prior to challenge with the antigen, totally prevented the disruption of intestinal motil ity and the development of anaphylaxis provoked diarrhea and inhibited anaphylactic hypotension by 66%. Submandibular gland peptides partici pate in the regulation of systemic inflammatory reactions, and the D-a mino acid tripeptide, feG, is a potent, orally active anti-anaphylacti c agent. (C) 1998 Elsevier Science Inc.