KINETIC RESOLUTION OF ARYL GLYCIDYL ETHERS - A PRACTICAL SYNTHESIS OFOPTICALLY PURE BETA-BLOCKER - S-METOPROLOL

Authors
GURJAR MK SADALAPURE K ADHIKARI S SARMA BVNBS TALUKDAR A CHORGHADE MS
Citation
Mk. Gurjar et al., KINETIC RESOLUTION OF ARYL GLYCIDYL ETHERS - A PRACTICAL SYNTHESIS OFOPTICALLY PURE BETA-BLOCKER - S-METOPROLOL, Heterocycles, 48(7), 1998, pp. 1471-1476
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
7
Year of publication
1998
Pages
1471 - 1476
Database
ISI
SICI code
0385-5414(1998)48:7<1471:KROAGE>2.0.ZU;2-X
Abstract
Kinetic resolution of (+/-)-aryl glycidyl ethers using (R,R)-salen Co( III)OAc and water provided enantiomerically pure arylglycidyl ether an d 1-arylglycerol derivatives with high enantiomeric excess. Applicatio n of this approach to (S)-metoprolol has been described.