NEW TYPES OF LIPOSIDOMYCINS THAT INHIBIT BACTERIAL PEPTIDOGLYCAN SYNTHESIS AND ARE PRODUCED BY STREPTOMYCES - 1 - PRODUCING ORGANISM AND MEDIUM COMPONENTS

Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was iden tified as a Streptomyces sp. from its cultural characteristics and phy siological properties. It produced new types of liposidomycins that la cked sulfate and/or 3-methylglutaric acid moieties present in known li posidomycins by changing medium components. Sucrose and malt extract w ere particularly suitable sources for specific production of the new t ypes of liposidomycins.