NEW TYPES OF LIPOSIDOMYCINS THAT INHIBIT BACTERIAL PEPTIDOGLYCAN SYNTHESIS AND ARE PRODUCED BY STREPTOMYCES - II - ISOLATION AND STRUCTURE ELUCIDATION

Various new liposidomycins were isolated from a-culture of the strain Streptomyces sp. SN-1061M by changing medium components and they were classified into four types (I similar to IV) based on their structures . They were purified by butanol extraction, silica gel and LH-20 colum n chromatographies, nd high performance liquid chromatography on ODS c olumns; Type (I) has the original structure which has sulfate and 3-me thylglutaric acid moieties. Type (II) has no 3-methylglutaric acid moi ety and type (III) has no sulfate moiety. Type (IV) has neither moiety . Type (III) and (IV) compounds, which have no sulfate moiety, exhibit ed more potent antimicrobial activity.