A NEW PLLA PCL COPOLYMER FOR NERVE REGENERATION

Citation
Wfa. Dendunnen et al., A NEW PLLA PCL COPOLYMER FOR NERVE REGENERATION, Journal of materials science. Materials in medicine, 4(5), 1993, pp. 521-525
Citations number
21
Categorie Soggetti
Material Science","Polymer Sciences","Medicine Miscellaneus
ISSN journal
09574530
Volume
4
Issue
5
Year of publication
1993
Pages
521 - 525
Database
ISI
SICI code
0957-4530(1993)4:5<521:ANPPCF>2.0.ZU;2-B
Abstract
The aim of this study is to evaluate the functional and cell biologica l applicability of a two-ply nerve guide constructed of a PLLA/PCL (i. e. poly-L-lactide and poly-epsilon-caprolactone) copolymer. To do so, we performed a cytotoxicity test, a subcutaneous biodegradation test a nd an in situ implantation study in the sciatic nerve of the rat. The nerve guide copolymer was found to be non-toxic, according to ISO/EN s tandards, and it showed a mild foreign body reaction and complete fibr ous encapsulation after implantation. Onset of biodegradation of the i nner layer was seen after one month of implantation. After 1 8 months of implantation complete fragmentation was observed, as well as a seco ndary inflammatory response. characterized by foreign body giant cell activity and phagocytosis of polymer debris. Recovery of both motor an d sensory nerve function was observed in all nerve guides.