GENE-REGULATION BY Y-BOX PROTEINS - COUPLING CONTROL OF TRANSCRIPTIONAND TRANSLATION

Citation
K. Matsumoto et Ap. Wolffe, GENE-REGULATION BY Y-BOX PROTEINS - COUPLING CONTROL OF TRANSCRIPTIONAND TRANSLATION, Trends in cell biology, 8(8), 1998, pp. 318-323
Citations number
53
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
09628924
Volume
8
Issue
8
Year of publication
1998
Pages
318 - 323
Database
ISI
SICI code
0962-8924(1998)8:8<318:GBYP-C>2.0.ZU;2-F
Abstract
Y-box proteins are multifunctional regulators of gene expression. In s omatic cells, they have the capacity to exert positive and negative ef fects on both transcription and translation. In Xenopus oocytes, they help to mask maternal mRNA and couple the transcription of mRNA in the nucleus to its translational fate in the cytoplasm. This review descr ibes how the capacity of the Y-box proteins to destabilize both RNA an d DNA duplexes, together with their distribution between nuclear and c ytoplasmic compartments, might explain these multiple roles.