K. Matsumoto et Ap. Wolffe, GENE-REGULATION BY Y-BOX PROTEINS - COUPLING CONTROL OF TRANSCRIPTIONAND TRANSLATION, Trends in cell biology, 8(8), 1998, pp. 318-323
Y-box proteins are multifunctional regulators of gene expression. In s
omatic cells, they have the capacity to exert positive and negative ef
fects on both transcription and translation. In Xenopus oocytes, they
help to mask maternal mRNA and couple the transcription of mRNA in the
nucleus to its translational fate in the cytoplasm. This review descr
ibes how the capacity of the Y-box proteins to destabilize both RNA an
d DNA duplexes, together with their distribution between nuclear and c
ytoplasmic compartments, might explain these multiple roles.