A 3-year-old castrated male domestic ferret was evaluated for abdomina
l distention. Survey lateral and dorsoventral abdominal radiographs we
re made. There were two soft tissue radiopacities consistent with gros
sly enlarged kidneys displacing small bowel and colon cranially, ventr
ally and caudally, Abdominal ultrasound was performed and revealed bil
ateral perinephric pseudocysts and polycystic kidneys. The perinephric
pseudocysts were found to be dilated renal capsules on exploratory su
rgery and were drained. On follow up examinations, the pseudocysts wer
e drained by ultrasound-guided paracentesis, The perinephric cyst flui
d was distinguished from urine by measuring creatinine concentration a
nd plans were made to resect the renal capsules due to rapid re-accumu
lation of pseudocyst fluid. The ferret's condition deteriorated and eu
thanasia was performed. Post-mortem examination was declined by the ow
ner, Perinephric pseudocysts are rare and this is the first published
report in a ferret. Ultrasound examination is the most rapid, accurate
and non-invasive method for diagnosis of perinephric pseudocysts.