Networks of interacting transcription factors, or gene circuits, form
an essential part of the metabolic pathways controlling macromolecular
synthesis. This paper conveys two new results about gene circuits. We
first show how a gene circuit for mutant phenotypes can be constructe
d from the wild type gene circuit for the same organism. We then prese
nt results of computational studies that show that mutant expression p
atterns can be correctly predicted using gene circuits whose parameter
s have been determined from wild type data only. Further computational
studies demonstrate that this property is insensitive to errors as la
rge as a factor of two in the input data. Together, these results show
that gene circuits can be used to identify the regulatory mechanisms
governing an entire family of genotypes from a knowledge of the wild t
ype genotype alone. It is argued that this fact forms the basis for a
new paradigm in genetics. (C) 1998 Elsevier Science Ireland Ltd. All r
ights reserved.