UNEXPECTED AND FACILE BRIDGEHEAD SUBSTITUTION IN AHYDRO-5,9-METHANOPYRIMIDO[4,5-B]AZOCIN-4(3H)-ONES

Authors
TAYLOR EC DOWLING JE SCHRADER T BHATIA B
Citation
Ec. Taylor et al., UNEXPECTED AND FACILE BRIDGEHEAD SUBSTITUTION IN AHYDRO-5,9-METHANOPYRIMIDO[4,5-B]AZOCIN-4(3H)-ONES, Tetrahedron, 54(33), 1998, pp. 9507-9518
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
33
Year of publication
1998
Pages
9507 - 9518
Database
ISI
SICI code
0040-4020(1998)54:33<9507:UAFBSI>2.0.ZU;2-G
Abstract
Condensation of 2,6-diamino-4(3 (H) under bar)-pyrimidinone with 2-cyc lohexen-1-one gives a tricyclic product resulting from Michael additio n followed by intramolecular hemiaminal formation. A methodology has b een developed for reductive removal of the bridgehead hydroxyl group. (C) 1998 Elsevier Science Ltd. All rights reserved.