Ec. Taylor et al., UNEXPECTED AND FACILE BRIDGEHEAD SUBSTITUTION IN AHYDRO-5,9-METHANOPYRIMIDO[4,5-B]AZOCIN-4(3H)-ONES, Tetrahedron, 54(33), 1998, pp. 9507-9518
Condensation of 2,6-diamino-4(3 (H) under bar)-pyrimidinone with 2-cyc
lohexen-1-one gives a tricyclic product resulting from Michael additio
n followed by intramolecular hemiaminal formation. A methodology has b
een developed for reductive removal of the bridgehead hydroxyl group.
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