RTI-113 ADMINISTRATION REDUCES COCAINE SELF-ADMINISTRATION AT HIGH OCCUPANCY OF DOPAMINE TRANSPORTER

Authors
DWORKIN SI LAMBERT P SIZEMORE GM CARROLL FI KUHAR MJ
Citation
Si. Dworkin et al., RTI-113 ADMINISTRATION REDUCES COCAINE SELF-ADMINISTRATION AT HIGH OCCUPANCY OF DOPAMINE TRANSPORTER, Synapse, 30(1), 1998, pp. 49-55
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Synapse → ACNP
ISSN journal
08874476
Volume
30
Issue
1
Year of publication
1998
Pages
49 - 55
Database
ISI
SICI code
0887-4476(1998)30:1<49:RARCSA>2.0.ZU;2-R
Abstract
RTI-113 [3 beta-(4-chlorophenyl)tropan-2 beta carboxylic acid phenyl e ster hydrochloride], one of many phenyltropanes potent at and selectiv e for DAT, inhibited self-administration of cocaine in rat, at doses t hat did not alter responding maintained by food. The doses that inhibi ted cocaine intake produced significant levels of occupancy of DAT. Sy napse 30:49-55, 1998. (C) Wiley-Liss, Inc., Inc.