GASTROINTESTINAL PERFORATION EARLY AFTER PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION FOR AL AMYLOIDOSIS

The morbidity and mortality of AL amyloidosis is caused by the deposit ion of Ig light chains as amyloid protein in vital organs. With conven tional therapy median survival of patients with AL amyloidosis is 10-1 4 months. With high-dose chemotherapy clinical remissions of organ-spe cific disease have been reported. Here, we present a patient with high -risk AL amyloidosis who was given high-dose therapy and a peripheral blood stem cell transplant. Four days later she died of gastrointestin al perforation due to amyloid infiltrations.