ACANTHAMOEBA MENINGOENCEPHALITIS FOLLOWING AUTOLOGOUS PERIPHERAL STEM-CELL TRANSPLANTATION

Citation
Jm. Feingold et al., ACANTHAMOEBA MENINGOENCEPHALITIS FOLLOWING AUTOLOGOUS PERIPHERAL STEM-CELL TRANSPLANTATION, Bone marrow transplantation, 22(3), 1998, pp. 297-300
Citations number
11
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
ISSN journal
02683369
Volume
22
Issue
3
Year of publication
1998
Pages
297 - 300
Database
ISI
SICI code
0268-3369(1998)22:3<297:AMFAPS>2.0.ZU;2-M
Abstract
Amoebic meningoencephalitis is an unusual complication of hone marrow transplantation. We report a case of Acanthamoeba meningoencephalitis in a patient with non-Hodgkin's lymphoma after autologous stem cell tr ansplantation. Leg weakness, fever and urinary retention developed 69 days following transplantation. The patient then developed fever, gene ralized tonic clonic seizure, rapid deterioration of mental functions and hypercapneic respiratory failure. Magnetic resonance imaging demon strated a ring enhancing lesion at the level of the thoracic spines 11 and 12. Examination of the cerebrospinal fluid revealed pleocytosis. Despite empiric therapy with broad-spectrum antimicrobial agents, the patient's condition worsened and she died II days following admission. Autopsy findings revealed a subacute meningoencephalitis secondary to Acanthamoeba culbertsoni.