A CASE OF EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISEASE FOLLOWING HIGH-DOSE THERAPY AND CD34-PURIFIED AUTOLOGOUS PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION

A fatal case of EBV-associated lymphoproliferative disorder arising af ter a CD33-selected autologous peripheral blood stem cell transplant i s reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accesso ry cell depletion associated with the CD34(+) cell purification and it is recommended that a source of autologous T cells is stored before t ransplantation to be used if a severe opportunistic infection or EBV l ymphoma arises post-transplantation.