Jkn. Kuria et al., GASEOUS LYMPHADENITIS IN GOATS - THE DOSE OF INFECTION AND THE SEROLOGICAL RESPONSE, Indian Journal of Animal Sciences, 68(7), 1998, pp. 601-604
Goats were infected intradermally with caseous pus containing between
1 x 10(5) and 5 x 10(1) colony forming units (CFU) of Corynebacterium
pseudotuberculosis. Animals infected with doses of equal and above 1 x
10(2) CFU of the organism developed caseous lesions in regional drain
ing lymphnodes while those infected with lesser doses developed none.
On serological examination, 3/6 animals infected with equal to or less
than 1 x 10(3) CFU and 2/4 infected with equal to or less than 1 x 10
(2) CFU had no positive bacterial agglutination and antitoxin antibody
titres respectively. These results indicated that caseous lymphadenit
is (CLA) is a highly contagious disease since a relatively low dose (1
x 10(2) CFU) of C. pseudotuberculosis injected intradermally could in
duce CLA lesions in draining lymphnodes. The serological response in t
erms and rate and extent appeared to depend on the dose of infection.