ANTIPLATELET AND ANTITHROMBOTIC EFFECTS OF A COMBINATION OF TICLOPIDINE AND GINKGO-BILOBA EXT (EGB761)

The antiplatelet and antithrombotic effects of the oral combination tr eatment of ticlopidine and Ginkgo biloba extract (EGb 761) were studie d in normal and thrombosis-induced rats. The ex vivo inhibitory effect on ADP-induced platelet aggregation of a small dose of ticlopidine (5 0 mg/kg/day) in combination with EGb 761 (40 mg/kg/day) was comparable to a larger dose of only ticlopidine (200 mg/kg/day). Bleeding time w as also prolonged by 150%. Thrombus weight was also consistently decre ased by a combination of ticlopidine and EGb 761 in an arterio-venous shunt model at two doses of ticlopidine (50 mg/kg) plus EGb 761 (20 mg /kg) and ticlopidine (50 mg/kg) plus EGb 761 (40 mg/kg). A combinatory treatment in acute thrombosis model in mice also showed a higher reco very than a single treatment. (C) 1998 Elsevier Science Ltd.