EFFECT OF SURFACTANTS ON PEROXIDASE-ACTIVITY - I - EFFECT OF ANIONIC SURFACTANTS

Authors
DAVLETSHIN AI EGOROV VV ZUBOV VP
Citation
Ai. Davletshin et al., EFFECT OF SURFACTANTS ON PEROXIDASE-ACTIVITY - I - EFFECT OF ANIONIC SURFACTANTS, Bioorganiceskaa himia, 24(6), 1998, pp. 426-429
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
24
Issue
6
Year of publication
1998
Pages
426 - 429
Database
ISI
SICI code
0132-3423(1998)24:6<426:EOSOP->2.0.ZU;2-Q
Abstract
The effect of various anionic surfactants on the initial rate of 5-ami nosalicylic acid peroxidation with horseradish peroxidase was studied. With increasing surfactant concentration, this rate first decreased, then increased, and again decreased. We conclude that these changes we re due to an inhibition of the enzyme, a subsequent change in the enzy me conformation accompanied by the enhanced accessibility of its activ e site to the substrate, and the final protein denaturation, respectiv ely.