INHIBITION OF ICOSANOID PRODUCTION IN MC 9 MOUSE MAST-CELLS BY N-3 POLYUNSATURATED FATTY-ACIDS ISOLATED FROM EDIBLE MARINE-ALGAE/

Authors
ISHIHARA K MURATA M KANENIWA M SAITO H SHINOHARA K MAEDAYAMAMOTO M
Citation
K. Ishihara et al., INHIBITION OF ICOSANOID PRODUCTION IN MC 9 MOUSE MAST-CELLS BY N-3 POLYUNSATURATED FATTY-ACIDS ISOLATED FROM EDIBLE MARINE-ALGAE/, Bioscience, biotechnology, and biochemistry, 62(7), 1998, pp. 1412-1415
Citations number
17
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
7
Year of publication
1998
Pages
1412 - 1415
Database
ISI
SICI code
0916-8451(1998)62:7<1412:IOIPIM>2.0.ZU;2-S
Abstract
The effects of two polyunsaturated fatty acids, 18:4n-3 and 16:4n-3 pu rified from the marine algae, Undaria pinnatifida and Ulva pertusa, on icosanoid production in MC/9 mouse mast cells were assessed. Both fat ty acids suppressed the production of leukotriene B-4 (LTB4), leukotri ene C-4 (LTC4), and 5-hydroxyeicosatetraenoic acid (5-HETE). The order of the suppressive activity for the two marine algae-derived fatty ac ids and three other common polyunsaturated fatty acids was as follows; 22:4n3 = 18:3n-3 = 18:3n-3 > 20:5n-3 = 16:4n-3 for LTB4; 22:6n-3 = 18 :4n-3 = 18:3n-3 > 16:4n-3 > 20:5n-3 (no suppression) for LTC4; 22:6n-3 = 18:4n-3 > 18:3n-3 > 20:5n-3 = 16:4n-3 for 5-HETE.