SUPPRESSION OF SENESCENCE IN NORMAL HUMAN FIBROBLASTS BY INTRODUCTIONOF DOMINANT-NEGATIVE P53 MUTANTS OR HUMAN PAPILLOMA-VIRUS TYPE-16 E6 PROTEIN

Authors
IDE A FUJII M NAKABABASHI K AYUSAWA D
Citation
A. Ide et al., SUPPRESSION OF SENESCENCE IN NORMAL HUMAN FIBROBLASTS BY INTRODUCTIONOF DOMINANT-NEGATIVE P53 MUTANTS OR HUMAN PAPILLOMA-VIRUS TYPE-16 E6 PROTEIN, Bioscience, biotechnology, and biochemistry, 62(7), 1998, pp. 1458-1460
Citations number
10
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
7
Year of publication
1998
Pages
1458 - 1460
Database
ISI
SICI code
0916-8451(1998)62:7<1458:SOSINH>2.0.ZU;2-L
Abstract
Transfection of nearly senesced human fibroblasts with plasmids encodi ng HPV16 E6 protein or dominant-negative p53 mutants greatly increased their colony-forming ability. Isolated colonies with these plasmids s helved extension of lifespan compared to those with a control plasmid. These data demonstrate that p53 plays a major role in senescence in n ormal human fibroblasts.