THE SIDE-EFFECT BURDEN ASSOCIATED WITH DRUG-TREATMENT OF PANIC DISORDER

This article reviews the incidences of side effects in placebo-control led clinical trials of drug therapy in patients with panic disorder. W e performed a MEDLINE search for placebo-controlled studies in panic d isorder that reported the incidences of side effects, published in Eng lish language, peer-reviewed journals between 1992 and 1997. We discus s the side effects experienced by patients receiving tricyclic antidep ressants, serotonin selective reuptake inhibitors, and benzodiazepines , the drug classes most commonly prescribed for the treatment of panic disorder. Available evidence suggests that, with respect to tolerabil ity, serotonin selective reuptake inhibitors are the most favorable tr eatment choice for patients with panic disorder.