SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHATES CONTAINING 6-THIO-SUBSTITUTED PURINE NUCLEOBASES

Authors
CLIVIO P FOURREY JL FAVRE A
Citation
P. Clivio et al., SYNTHESIS OF DEOXYDINUCLEOSIDE PHOSPHATES CONTAINING 6-THIO-SUBSTITUTED PURINE NUCLEOBASES, Journal of the Chemical Society. Perkin transactions. I, (21), 1993, pp. 2585-2590
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
21
Year of publication
1993
Pages
2585 - 2590
Database
ISI
SICI code
0300-922X(1993):21<2585:SODPC6>2.0.ZU;2-A
Abstract
An efficient preparative method to obtain. by the hydrogen phosphonate approach in solution, dinucleoside phosphates containing either 2'-de oxy-6-thioinosine or 2'-deoxy-6-thioguanosine at their 3' end, as in c ompounds 6 and 7, is described. For this purpose appropriate 5'-OH-fre e sulfur-modified deoxynucleoside intermediates required for this synt hesis have been defined, as exemplified with the case of 2'-deoxy-6-th ioguanosine.