NOVEL BIOACTIVE THIOCARBAZIDE AND SEMICARBAZIDE LIGANDS AND THEIR ORGANOSILICON(IV) AND ORGANOTIN(IV) COMPLEXES

Stereochemical and biochemical aspects of organosilicon(fr) and organo tin(IV)) complexes with thio- and semicarbazide ligands having NS and NO donor systems are described with the support of elemental analysis, IR, LH, C-13 NMR, Si-29 NMR, Sn-119 NMR and F-19 NMR spectroscopy. Fr om the analysis of these studies the donor sites of ligands are locate d and the geometries of donor environment around the satin(IV) and sil icon(IV) acceptor centres proposed. The ligands and their metal comple xes are tested in vitro and in vivo by a new technique against a numbe r of pathogenic fungal and bacterial strains and the findings are disc ussed.