STREPTOPYRROLE - AN ANTIMICROBIAL METABOLITE FROM STREPTOMYCES-ARMENIACUS

A colourless, crystalline metabolite, C14H12ClNO4, named streptopyrrol e, has been isolated from submerged fermentation cultures of Streptomy ces armeniacus by extraction, followed by chromatographic purification . Its tricyclic molecular framework, seemingly without natural product precedents. as well as its substitution pattern were derived from ext ensive NMR analysis including H-1-detected INADEQUATE experiments. Str eptopyrrole exhibits weak growth inhibitory effect towards a broad ran ge of microorganisms.