The aim of the study was to examine the presence of hyperalgesia to he
at stimuli within the zone of secondary hyperalgesia to punctate mecha
nical stimuli. A burn was produced on the medial part of the non-domin
ant crus in 15 healthy volunteers with a 50 x 25 mm thermode (47 degre
es C, 7 min), and assessments were made 70 min and 40 min before, and
0, 1, and 2 h after the burn injury. Hyperalgesia to mechanical and he
at stimuli were examined by von Frey hairs and contact thermodes (3.75
and 12.5 cm(2)), and pain responses were rated with a visual analog s
cale (0-100). The area of secondary hyperalgesia to punctate stimuli w
as assessed with a rigid von Prey hair (462 mN). The heat pain respons
es to 45 degrees C in 5 s (3.75 cm(2)) were tested in the area just ou
tside the burn, where the subjects developed secondary hyperalgesia, a
nd on the lateral crus where no subject developed secondary hyperalges
ia (control area). The burns decreased pain thresholds and increased p
ain responses to both thermal and mechanical stimuli within the burn (
P < 10(-5)). Further, the bums induced secondary hyperalgesia (mean 89
cm(2)) to punctate mechanical stimuli (P < 10(-5)), and increased the
pain response to mechanical stimuli in the areas of secondary hyperal
gesia (P < 10(-5)). The pain response to heat stimuli increased over t
ime in the area of secondary hyperalgesia (P < 10(-5)), and so did the
pain response to heat on the lateral part of the crus (P < 10(-3)). H
owever, the heat pain response increased more (P = 0.006) and was more
intense (P = 0.001) within the zone of secondary hyperalgesia than on
the lateral part of the crus. Further, the heat pain response was mor
e intense in the zone of primary hyperalgesia than in the zone of seco
ndary hyperalgesia (P = 0.004), in contrast to the mechanical pain res
ponse, which was not significantly different between the two zones of
hyperalgesia. In conclusion, secondary hyperalgesia in man is not rest
ricted to mechanical stimuli, as significant hyperalgesia to heat deve
loped within the zone of secondary hyperalgesia to punctate mechanical
stimuli. The data, combined with other evidence, suggest differences
in the mechanisms accounting for primary hyperalgesia to heat and mech
anical stimuli, whereas secondary hyperalgesia to heat and mechanical
stimuli may be explained by a common central mechanism. (C) 1998 Inter
national Association for the Study of Pain. Published by Elsevier Scie
nce B.V.