M. Filippi et al., A LONGITUDINAL BRAIN MRI STUDY COMPARING THE SENSITIVITIES OF THE CONVENTIONAL AND A NEWER APPROACH FOR DETECTING ACTIVE LESIONS IN MULTIPLE-SCLEROSIS, Journal of the neurological sciences, 159(1), 1998, pp. 94-101
Monthly dual-echo spin-echo (SE) and enhanced magnetic resonance imagi
ng (MRI) after the injection of a standard dose (SD) of gadolinium (Gd
) is the conventional approach to monitor short-term disease activity
in multiple sclerosis (MS). In this study, the sensitivity of this app
roach in detecting active lesions in MS was compared with that of mont
hly fast fluid attenuated inversion recovery (FLAIR) scans associated
with enhanced MRI after the injection of a triple dose (TD) of Gd. Thi
rteen patients with relapsing-remitting MS entered the study. Monthly
MRI scans were obtained on four occasions in two separate sessions (in
terval between 12 and 24 h). In one session, dual-echo conventional SE
and SD T1-weighted scans were obtained; in the other, fast-FLAIR and
TD T1-weighted scans. The order of the two sessions was randomized. Th
ree observers counted the numbers of active lesions detected by each o
f the two approaches. One hundred and four active lesions were detecte
d by the conventional approach and 199 by the newer approach (average
increase per patient=75%, range=0-325%). The mean number of active les
ions per month per patient was 2.0 for the conventional approach and 3
.8 for the new approach (P=0.004). Scans with active lesions were 34/5
2 (65%) with the conventional approach and 37/52 (71%) with the new ap
proach. Our data indicate that the combined use of monthly fast-FLAIR
and TD enhanced T1-weighted scans increases the number of active lesio
ns detected on serial MRT scans from patients with MS. (C) 1998 Elsevi
er Science B.V. All rights reserved.