SYNTHESIS AND STUDY OF A DIPYRIDAMOLE PRODRUG - APPLICATION OF THE ADEPT STRATEGY TO THE MDR RESISTANCE IN CANCER-CHEMOTHERAPY

Authors
SCHMIDT F FLORENT JC MONNERET C
Citation
F. Schmidt et al., SYNTHESIS AND STUDY OF A DIPYRIDAMOLE PRODRUG - APPLICATION OF THE ADEPT STRATEGY TO THE MDR RESISTANCE IN CANCER-CHEMOTHERAPY, COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE, 1(7), 1998, pp. 421-424
Citations number
10
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE → ACNP
ISSN journal
13871609
Volume
1
Issue
7
Year of publication
1998
Pages
421 - 424
Database
ISI
SICI code
1387-1609(1998)1:7<421:SASOAD>2.0.ZU;2-7
Abstract
A glucuronyl-spacer-dipyridamole prodrug has been synthesized from dip yridamole, a reversal agent of MDR. Combined use of this compound with a glucuronyl-spacer-doxorubicin prodrug (HMR 1826), restored in vitro the sensibility of a resistant cancerous strain. This prodrug was the refore selected for in vivo tests according to ADEPT strategy on MDR r esistance expressing rumours. (C) Academie des sciences/Elsevier, Pari s.