J. Zweit et al., EXCITATION-FUNCTIONS OF PROTON-INDUCED REACTIONS ON COBALT - PRODUCTION OF NO-CARRIER ADDED NI-57, A POSITRON EMITTING LABEL FOR DOXORUBICIN, Applied radiation and isotopes, 44(12), 1993, pp. 1411-1416
Citations number
18
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Excitation functions were measured, by the stacked-foil technique, for
the Co-59(p, 3n)Ni-57 and Co-59(p, 4n)Ni-56 nuclear reactions from th
reshold up to 60 MeV. The excitation function for the Co-59(p, 3n)Ni-5
7 reaction shows a maximum cross section of 13.8 +/- 1.5 mb at 38 MeV.
The optimum energy range for production of Ni-57 was found to be 41 -
-> 26 MeV resulting in an experimental thick target yield of 19.3 MBq/
muAh) (522 muCi/muAh). The level of the Ni-56 impurity is only 0.21% a
t EOB giving a Ni-57 product of 99.7% radionuclide purity at the time
of use (24 h post EOB). Cross section data for the production of Ni-56
, Co-56, Co-57, Co-58, Mn-52, Mn-54 and Cr-51 are also presented. A ra
diochemical procedure, based on cation-exchange chromatography, for th
e separation of radionickel from an activated cobalt target and other
radiochemical and chemical impurities, has been developed. The Ni-57 a
ctivity was eluted, using 2 M HCl from a Dowex-50W x 8(H+) column, in
a 95% radiochemical yield (15 mL). The Ni-57 has been used to label th
e anti-cancer drug, doxorubicin, thereby providing the means for pharm
acokinetic and pharmacodynamic studies of this compound using positron
emission tomography. The labelling has been optimized to give a radio
chemical yield of >94%.