IN-TARGET PRODUCTION OF [N-13] AMMONIA - TARGET DESIGN, PRODUCTS, ANDOPERATING PARAMETERS

[N-13]Ammonia, commonly used in PET, has been prepared in good yield i n the target. Up to 800 mCi of radiopharmaceutical was obtained by in- line processing of the irradiated water. Relatively low hydrogen press ure was used to control the target chemistry. Target designs and the p roduct dependence on beam dose, dose rate and pressure are reported. E thanol as a target additive was also investigated. Hydrogen and ethano l together were more effective than either alone at high beam dose. Pa rameters are reported for production needs from single doses to synthe tic applications. An incidental method for production of [N-13]nitroge n gas is also reported.