PHOSPHOLIPID-COMPOSITION IN SPINAL-CORD REGIONS AFTER ISCHEMIA REPERFUSION/

Ischemia-reperfusion induced changes in concentration of phosphatidylc holine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), p hosphatidylinositol (PI) and sphingomyelin (SM) in the gray matter tak en in tote, white matter, dorsal hems, intermediate zone and ventral h ems of the rabbit's spinal cord were studied and compared with neurohi stopathological changes. With the exception of PI concentration in the dorsal hems, ischemia of 25 min caused significant degradation of all phospholipids. While short-lasting recirculation (1 h) did not return ed the levels of phospholipids to control values, postischemic recircu lation for 3 h sharply increased the resynthesis of all phospholipids, but only the concentration of PE, PS, and PI in the dorsal horns and PC in the intermediate zone significantly improved and returned close to control values. Corresponding neurohistopathological changes result ing after the same reperfusion periods are given.