HISTORICAL PROSPECTIVE COHORT STUDY OF THE RECURRENCE OF PAIN AFTER DISCONTINUATION OF TREATMENT WITH DANAZOL OR A GONADOTROPIN-RELEASING-HORMONE AGONIST
Jd. Miller et al., HISTORICAL PROSPECTIVE COHORT STUDY OF THE RECURRENCE OF PAIN AFTER DISCONTINUATION OF TREATMENT WITH DANAZOL OR A GONADOTROPIN-RELEASING-HORMONE AGONIST, Fertility and sterility, 70(2), 1998, pp. 293-296
Objective: To determine the duration of time to the recurrence of pain
attributable to endometriosis after the discontinuation of treatment
with danazol or a GnRH agonist (GnRH-a) in patients who have had a sat
isfactory response to the treatment. Design: Retrospective study. Sett
ing: Nine academic medical centers in three countries. Patient(s): Thr
ee hundred twenty-seven women with diagnosed and staged endometriosis
who were treated with at least 6 months of danazol or a GnRH-a and who
experienced significant pain relief with therapy. Intervention(s): No
ne. Main Outcome Measure(s): Duration of pain relief after completion
of treatment as determined by a patient-initiated report of pain recur
rence or increase in pain severity requiring intervention. Result(s):
The median time to the recurrence of pain was 6.1 months for patients
treated with danazol and 5.2 months for patients treated with a GnRH-a
. Conclusion(s): Although there was a lack of uniformity in treatment
effects across sites, the analyses have taken into account major covar
iant effects. The time to the recurrence of endometriosis-associated p
ain after danazol treatment was slightly longer than that after GnRH-a
treatment. (Fertil Steril(R) 0;70:293-6. (C)1998 by American Society
for Reproductive Medicine.).