ANTIHISTOPLASMAL IN-VITRO AND IN-VIVO EFFECT OF LYS-NVA-FMDP

Authors
MILEWSKI S MIGNINI F MICOSSI L BOROWSKI E
Citation
S. Milewski et al., ANTIHISTOPLASMAL IN-VITRO AND IN-VIVO EFFECT OF LYS-NVA-FMDP, MEDICAL MYCOLOGY, 36(3), 1998, pp. 177-180
Citations number
17
Categorie Soggetti
Mycology,"Veterinary Sciences
Journal title
MEDICAL MYCOLOGY → ACNP
ISSN journal
13693786
Volume
36
Issue
3
Year of publication
1998
Pages
177 - 180
Database
ISI
SICI code
1369-3786(1998)36:3<177:AIAIEO>2.0.ZU;2-O
Abstract
The new synthetic antifungal agent, L-Lysyl-L-Norvalyl-FMDP, inhibits growth of the yeast form of Histoplasma capsulatum. The compound is tr ansported into the fungal cells by peptide permeases, cleaved intracel lularly to constitutive amino acids, and the released C-terminal amino acid inhibits glucosamine-6-phosphate synthase. Promising antihistopl asmal in vivo activity of the FMDP-peptide was observed in an organ lo ad test in mice.