PRADIMICIN THERAPY OF DISSEMINATED CANDIDA-TROPICALIS INFECTION IN THE MOUSE

Authors
RESTREPO MI NAJVAR LK FOTHERGILL AW GRAYBILL JR
Citation
Mi. Restrepo et al., PRADIMICIN THERAPY OF DISSEMINATED CANDIDA-TROPICALIS INFECTION IN THE MOUSE, MEDICAL MYCOLOGY, 36(3), 1998, pp. 181-184
Citations number
6
Categorie Soggetti
Mycology,"Veterinary Sciences
Journal title
MEDICAL MYCOLOGY → ACNP
ISSN journal
13693786
Volume
36
Issue
3
Year of publication
1998
Pages
181 - 184
Database
ISI
SICI code
1369-3786(1998)36:3<181:PTODCI>2.0.ZU;2-0
Abstract
EMS 181184 (BMS), an analogue of pradimicin, was administered intraven ously to neutropenic mice infected with either a fluconazole-susceptib le or a fluconazole-resistant clinical isolate of Candida tropicalis. EMS prolonged survival at doses >3 mg kg(-1) day(-1), and at higher do ses reduced tissue counts in mice. EMS was less potent mg for mg than amphotericin B. Combined EMS and amphotericin B were no more effective than either of the individual drugs.