In general, the most effective means of malaria vector control is the
killing of adult mosquitoes with a residual insecticide applied to bed
nets or sprayed on house walls and ceilings. Major reductions in all-c
ause child mortality have been achieved in Africa by these means. In s
ome circumstances, personal protection and larval control may also mak
e a contribution. We discuss the prospects of genetic control by relea
se of sterile male mosquitoes or driving genes for refractoriness to m
alaria into wild populations. Many major malaria vectors belong to com
plexes of sibling species which differ in vectorial and biological cha
racteristics. Distinguishing the species by cytogenetic or molecular m
ethods is important for epidemiological studies and could improve the
targeting of control.