NEW BETA-DIKETONE AND 3,5-DIMETHYL ISOXAZOLE DERIVATIVES OF THEOPHYLLINE AS POTENTIAL BRONCHODILATOR AGENTS

Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and lkyl]-3 ,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesize d and their bronchodilator activities investigated using the method ba sed on inhibition of acetylcholine and histamine-induced contractions in guinea pig trachea. None of the compounds were effective on acetylc holine-induced contractions. However, the compounds 4d, 4e, 5d and 5c were potent inhibitors of the bronchospasm induced by histamine, where as the others (4b, 4c, 5b and 5c) were weak inhibitors.