SODIUM FUSIDATE IN GUILLAIN-BARRE-SYNDROME - A CASE-REPORT

A patient with Guillain-Barre syndrome is reported on who responded fa vourably to a short course treatment with the novel immunosuppressant sodium fusidate (Fucidin), given at a daily dose of 1.5 g for one week . Along with prompt and clear cut clinical improvement, treatment with Fucidin was associated with a rapid decline in the blood concentratio ns of inflammatory cytokines presumably implicated in the pathogenesis of Guillain-Barre syndrome such as interleukin-2, interferon-gamma, a nd tumor necrosis factor-a. The ex vivo production of these cytokines was also markedly diminished compared with pretreatment values. Fucidi n was well tolerated and no clinical or biochemical side effects were seen.