Because of biological differences between men and women, the same quan
tity of alcohol consumed over the same time period produces higher blo
od alcohol levels (BALs) in women than in men. Some alcohol researcher
s have proposed that quantity and volume measures of alcohol consumpti
on (e.g. usual number of drinks per drinking day and overall amount of
alcohol consumed) should be adjusted to reflect these biological diff
erences. To date, no standard adjustment for biological gender differe
nces has been adopted. In this paper, we review the literature on biol
ogical and behavioral differences related to alcohol consumption and e
ffects and discuss the implications of these differences in terms of a
djusting alcohol consumption measures. Our review suggests that adjust
ing measures of alcohol consumption to compensate for biological sex d
ifferences is most appropriate for research or policy applications inv
olving the short and long-term physiological effects of alcohol in con
texts where gender differences in how alcohol is consumed can be assum
ed to be minimal. In other circumstances, non-biological gender differ
ences relating to alcohol use, such as pace of drinking, may moderate
the relationship between alcohol consumption and biological gender dif
ferences, making an adjustment less defensible. We also identify areas
where more Knowledge is needed not only to address the issue of adjus
ting alcohol measures for gender differences but also to understand be
tter the relationship between alcohol consumption and effects.