NEW ORGANOGERMYLATED COMPOUNDS N-SUBSTITUTED BY NAPHTHYLMETHYLIMIDAZOLINE HYDROCHLORIDE, AND IMIDAZOLINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY

Authors
RIMA G SATGE J SENTENACROUMANOU H FATOME M LION C LAVAL JD
Citation
G. Rima et al., NEW ORGANOGERMYLATED COMPOUNDS N-SUBSTITUTED BY NAPHTHYLMETHYLIMIDAZOLINE HYDROCHLORIDE, AND IMIDAZOLINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY, European journal of medicinal chemistry, 28(10), 1993, pp. 761-767
Citations number
29
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
10
Year of publication
1993
Pages
761 - 767
Database
ISI
SICI code
0223-5234(1993)28:10<761:NOCNBN>2.0.ZU;2-8
Abstract
This work concerns the synthesis and pharmacological study (toxicity, radioprotective activity) of the N-substituted organogermylated compou nds by naphthylmethylimidazoline hydrochloride and imidazoline. These new organometallic derivatives have quite low toxicity and sometimes h igher radioprotective activity (compared with hydrochlorides of naphth ylmethylimidazoline and imidazoline).