RECOMMENDATIONS ON IMMUNIZATION OF PATIENTS WITH CONDITIONS ASSOCIATED WITH GENERAL OR LIMITED IMMUNODEFICIENCIES

A revision of the literature was made as to the recommendations given for the use of vaccines and immune globulins in persons who presented total or partial. immunodeficiency, mainly related to the nineties. Th e analysis of 75 references led to the following principal conclusions : the vaccines containing living agents are generally inappropriate fo r persons who present conditions wich determine serious inmunodeficien cy; the vaccines wich contain dead agents or only antigenic fractions, despite their being [ess ir,immunogenic and confering lower rates of protection to severely immunocompromised persons as compared to normal persons, are safe and should be administered to them. Immunocompromis ed patients should receive immune globulins for the same indications n od in the snr,le doses as immunocompetent persons, with the exception Of immune globulin to prevent measles, as recommended in a dosage of 0 .5 mL/Kg for immunodeficients (15mL, maximum).