CHROMOSOMAL ASSIGNMENT OF 2 PUTATIVE CANINE KERATIN GENE CLUSTERS

Mutations in keratin genes account for a number of inherited keratoder mas in humans. The groups of basic and acidic keratin genes are cluste red on human chromosomes 12 and 17, respectively, The present authors have assigned the two putative keratin gene clusters to canine chromos omes using canine cosmid clones, Successful fluorescence in situ hybri dization mapped the putative cluster of canine acidic genes to dog chr omosome 20 and the putative cluster of basic keratin genes to a small autosome not yet included in the partial canine standard karyotype.